The human batokine EPDR1 regulates β-cell metabolism and function

The human batokine EPDR1 regulates β-cell metabolism and function

Objective: Ependymin-Related Protein 1 (EPDR1) was recently identified as a secreted human batokine regulating mitochondrial respiration linked to thermogenesis in brown fat. Despite that EPDR1 is expressed in human pancreatic β-cells and that glucose-stimulated mitochondrial metabolism is critical...

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Bibliographic Details
Main Authors: Luis Rodrigo Cataldo, Qian Gao, Lidia Argemi-Muntadas, Ondrej Hodek, Elaine Cowan, Sergey Hladkou, Sevda Gheibi, Peter Spégel, Rashmi B. Prasad, Lena Eliasson, Camilla Scheele, Malin Fex, Hindrik Mulder, Thomas Moritz
Format: Article
Language:English
Published: Elsevier 2022-12-01
Series:Molecular Metabolism
Subjects:
Mitochondrial metabolism
Lactate
TCA cycle
Beta cells
Insulin secretion
Type 2 diabetes
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877822001983

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http://www.sciencedirect.com/science/article/pii/S2212877822001983

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