Nano-Silica Carriers Coated by Chloramphenicol: Synthesis, Characterization, and Grinding Trial as a Way to Improve the Release Profile

Nano-Silica Carriers Coated by Chloramphenicol: Synthesis, Characterization, and Grinding Trial as a Way to Improve the Release Profile

Silica nanoparticles were applied as the carrier of chloramphenicol (2,2-dichloro-<i>N</i>-[(1<i>R</i>,2<i>R</i>)-1,3-dihydroxy-1-(4-nitrophenyl)propan-2-yl]acetamide), and were loaded in a 1% carbopol-based gel (poly(acrylic acid)), which allowed obtainment of an...

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Bibliographic Details
Main Authors: Radosław Balwierz, Dawid Bursy, Paweł Biernat, Nataliia Hudz, Mariia Shanaida, Łukasz Krzemiński, Paweł Skóra, Monika Biernat, Wioletta Ochędzan Siodłak
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Pharmaceuticals
Subjects:
silica carrier
release profile
dissolution study
carbopol
chloramphenicol nanoparticles
drug delivery
Online Access:https://www.mdpi.com/1424-8247/15/6/703

Internet

https://www.mdpi.com/1424-8247/15/6/703

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