Desmetramadol Is Identified as a G-Protein Biased µ Opioid Receptor Agonist

Desmetramadol Is Identified as a G-Protein Biased µ Opioid Receptor Agonist

Tramadol is widely used globally and is the second most prescribed opioid in the United States. It treats moderate to severe pain but lethal opioid-induced respiratory depression is uncommon even in large overdose. It is unknown why tramadol spares respiration. Here we show its active metabolite, de...

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Bibliographic Details
Main Authors: John A. Zebala, Aaron D. Schuler, Stuart J. Kahn, Dean Y. Maeda
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Pharmacology
Subjects:
respiratory depression
fentanyl
biased agonists
opioid crisis
CYP2D6
tramadol
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.01680/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.01680/full

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