Comparative Metabolomics and Transcriptomics Reveal Multiple Pathways Associated with Polymyxin Killing in <named-content content-type="genus-species">Pseudomonas aeruginosa</named-content>

Comparative Metabolomics and Transcriptomics Reveal Multiple Pathways Associated with Polymyxin Killing in <named-content content-type="genus-species">Pseudomonas aeruginosa</named-content>

ABSTRACT Polymyxins are a last-line therapy against multidrug-resistant Pseudomonas aeruginosa; however, resistance to polymyxins has been increasingly reported. Therefore, understanding the mechanisms of polymyxin activity and resistance is crucial for preserving their clinical usefulness. This stu...

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Bibliographic Details
Main Authors: Mei-Ling Han, Yan Zhu, Darren J. Creek, Yu-Wei Lin, Alina D. Gutu, Paul Hertzog, Tony Purcell, Hsin-Hui Shen, Samuel M. Moskowitz, Tony Velkov, Jian Li
Format: Article
Language:English
Published: American Society for Microbiology 2019-02-01
Series:mSystems
Subjects:
lipid A modification
metabolomics
Pseudomonas aeruginosa
transcriptomics
glycerophospholipids
lipopolysaccharide
Online Access:https://journals.asm.org/doi/10.1128/mSystems.00149-18

Internet

https://journals.asm.org/doi/10.1128/mSystems.00149-18

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