Circulation-Independent Differentiation Pathway from Extraembryonic Mesoderm toward Hematopoietic Stem Cells via Hemogenic Angioblasts

Circulation-Independent Differentiation Pathway from Extraembryonic Mesoderm toward Hematopoietic Stem Cells via Hemogenic Angioblasts

A large gap exists in our understanding of the course of differentiation from mesoderm to definitive hematopoietic stem cells (HSCs). Previously, we reported that Runx1+ cells in embryonic day 7.5 (E7.5) embryos contribute to the hemogenic endothelium in the E10.5 aorta-gonad-mesonephros (AGM) regio...

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Bibliographic Details
Main Authors: Yosuke Tanaka, Veronica Sanchez, Nozomu Takata, Tomomasa Yokomizo, Yojiro Yamanaka, Hiroshi Kataoka, Philipp S. Hoppe, Timm Schroeder, Shin-Ichi Nishikawa
Format: Article
Language:English
Published: Elsevier 2014-07-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124714004495

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http://www.sciencedirect.com/science/article/pii/S2211124714004495

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