Fingolimod (FTY720), a Sphinogosine-1-Phosphate Receptor Agonist, Mitigates Choroidal Endothelial Proangiogenic Properties and Choroidal Neovascularization

Fingolimod (FTY720), a Sphinogosine-1-Phosphate Receptor Agonist, Mitigates Choroidal Endothelial Proangiogenic Properties and Choroidal Neovascularization

Neovascular or wet age-related macular degeneration (nAMD) causes vision loss due to inflammatory and vascular endothelial growth factor (VEGF)-driven neovascularization processes in the choroid. Due to the excess in VEGF levels associated with nAMD, anti-VEGF therapies are utilized for treatment. U...

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Bibliographic Details
Main Authors: Christine M. Sorenson, Mitra Farnoodian, Shoujian Wang, Yong-Seok Song, Soesiawati R. Darjatmoko, Arthur S. Polans, Nader Sheibani
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Cells
Subjects:
age-related macular degeneration
inflammation
choroid
retinal pigment epithelium
retinal vasculature
microglia
Online Access:https://www.mdpi.com/2073-4409/11/6/969

Internet

https://www.mdpi.com/2073-4409/11/6/969

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