Increasing angiotensin-converting enzyme concentrations and absent angiotensin-converting enzyme activity are associated with adverse kidney outcomes in pediatric septic shock

Increasing angiotensin-converting enzyme concentrations and absent angiotensin-converting enzyme activity are associated with adverse kidney outcomes in pediatric septic shock

Abstract Background Sepsis-induced endothelial dysfunction is proposed to cause angiotensin-converting enzyme (ACE) dysfunction and renin–angiotensin–aldosterone system (RAAS) derangement, exacerbating vasodilatory shock and acute kidney injury (AKI). Few studies test this hypothesis directly, inclu...

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Bibliographic Details
Main Authors: Naomi Pode-Shakked, Giovanni Ceschia, James E. Rose, Stuart L. Goldstein, Natalja L. Stanski, the Genomics of Pediatric Septic Shock Investigators
Format: Article
Language:English
Published: BMC 2023-06-01
Series:Critical Care
Subjects:
Sepsis
Shock
Pediatrics
Acute kidney injury
Renin–angiotensin–aldosterone system
Angiotensin-converting enzyme
Online Access:https://doi.org/10.1186/s13054-023-04518-2

Internet

https://doi.org/10.1186/s13054-023-04518-2

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