Effects of a naturally occurring amino acid substitution in bovine PrP: a model for inherited prion disease in a natural host species

Effects of a naturally occurring amino acid substitution in bovine PrP: a model for inherited prion disease in a natural host species

Abstract Objective The most common hereditary prion disease is human Creutzfeldt-Jakob disease (CJD), associated with a mutation in the prion gene resulting in a glutamic acid to lysine substitution at position 200 (E200K) in the prion protein. Models of E200K CJD in transgenic mice have proven inte...

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Bibliographic Details
Main Authors: Catherine E. Vrentas, Justin J. Greenlee, Gregory H. Foster, James West, Marianna M. Jahnke, Mark T. Schmidt, Eric M. Nicholson
Format: Article
Language:English
Published: BMC 2017-12-01
Series:BMC Research Notes
Subjects:
Prion
CJD
Creutzfeldt-Jakob disease
E200K
E211K
Cattle
Online Access:http://link.springer.com/article/10.1186/s13104-017-3085-8

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http://link.springer.com/article/10.1186/s13104-017-3085-8

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