Decreased bone formation and increased osteoclastogenesis cause bone loss in mucolipidosis II

Decreased bone formation and increased osteoclastogenesis cause bone loss in mucolipidosis II

Abstract Mucolipidosis type II (MLII) is a severe multi‐systemic genetic disorder caused by missorting of lysosomal proteins and the subsequent lysosomal storage of undegraded macromolecules. Although affected children develop disabling skeletal abnormalities, their pathogenesis is not understood. H...

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Bibliographic Details
Main Authors: Katrin Kollmann, Jan Malte Pestka, Sonja Christin Kühn, Elisabeth Schöne, Michaela Schweizer, Kathrin Karkmann, Takanobu Otomo, Philip Catala‐Lehnen, Antonio Virgilio Failla, Robert Percy Marshall, Matthias Krause, Rene Santer, Michael Amling, Thomas Braulke, Thorsten Schinke
Format: Article
Language:English
Published: Springer Nature 2013-10-01
Series:EMBO Molecular Medicine
Subjects:
alendronate
interleukin‐6
mannose 6‐phosphate
mucolipidosis II
osteoclastogenesis
Online Access:https://doi.org/10.1002/emmm.201302979

Internet

https://doi.org/10.1002/emmm.201302979

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