Single-cell RNA sequencing reveals the suppressive effect of PPP1R15A inhibitor Sephin1 in antitumor immunity

Single-cell RNA sequencing reveals the suppressive effect of PPP1R15A inhibitor Sephin1 in antitumor immunity

Summary: Protein phosphatase 1 regulatory subunit 15A (PPP1R15A) is an important factor in the integrated stress response (ISR) in mammals and may play a crucial role in tumorigenesis. In our studies, we found an inhibitor of PPP1R15A, Sephin1, plays a protumorigenic role in mouse tumor models. By a...

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Bibliographic Details
Main Authors: Rongjing Wang, Yuchao Zhang, Shiwei Guo, Siyu Pei, Wei Guo, Zhenchuan Wu, Hailong Wang, Minghui Wang, Yizhe Li, Yufei Zhu, Ling-Hua Meng, Jingyu Lang, Gang Jin, Yichuan Xiao, Landian Hu, Xiangyin Kong
Format: Article
Language:English
Published: Elsevier 2023-02-01
Series:iScience
Subjects:
Biological sciences
Molecular biology
Immunology
Transcriptomics
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223000317

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http://www.sciencedirect.com/science/article/pii/S2589004223000317

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