Liver-specific rescuing of CEACAM1 reverses endothelial and cardiovascular abnormalities in male mice with null deletion of Ceacam1 gene

Liver-specific rescuing of CEACAM1 reverses endothelial and cardiovascular abnormalities in male mice with null deletion of Ceacam1 gene

Objective: Mice with global null mutation of Ceacam1 (Cc1−/−), display impairment of insulin clearance that causes hyperinsulinemia followed by insulin resistance, elevated hepatic de novo lipogenesis, and visceral obesity. In addition, they manifest abnormal vascular permeability and elevated blood...

Full description

Bibliographic Details
Main Authors: Lucia Russo, Harrison T. Muturi, Hilda E. Ghadieh, Alexander M. Wisniewski, Eric E. Morgan, Syed S. Quadri, Gavin P. Landesberg, Helmy M. Siragy, Guillermo Vazquez, Rosario Scalia, Rajesh Gupta, Sonia M. Najjar
Format: Article
Language:English
Published: Elsevier 2018-03-01
Series:Molecular Metabolism
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877817309997

Internet

http://www.sciencedirect.com/science/article/pii/S2212877817309997

Similar Items