Distinct immune stimulatory effects of anti-human VISTA antibodies are determined by Fc-receptor interaction

Distinct immune stimulatory effects of anti-human VISTA antibodies are determined by Fc-receptor interaction

VISTA (PD-1H) is an immune regulatory molecule considered part of the next wave of immuno-oncology targets. VISTA is an immunoglobulin (Ig) superfamily cell surface molecule mainly expressed on myeloid cells, and to some extent on NK cells and T cells. In previous preclinical studies, some VISTA-tar...

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Bibliographic Details
Main Authors: Sven Mostböck, Helen Haixia Wu, Timothy Fenn, Bettina Riegler, Susanne Strahlhofer, Yining Huang, Gale Hansen, Rachel Kroe-Barrett, Iñigo Tirapu, Anne B. Vogt
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Immunology
Subjects:
VISTA
antibody
Fc-receptor
immunotherapy
immune checkpoint
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.862757/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.862757/full

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