Neonatal immune challenge poses a sex-specific risk for epigenetic microglial reprogramming and behavioral impairment

Neonatal immune challenge poses a sex-specific risk for epigenetic microglial reprogramming and behavioral impairment

Abstract While the precise processes underlying a sex bias in the development of central nervous system (CNS) disorders are unknown, there is growing evidence that an early life immune activation can contribute to the disease pathogenesis. When we mimicked an early systemic viral infection or applie...

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Bibliographic Details
Main Authors: Marius Schwabenland, Omar Mossad, Annika Sievert, Adam G. Peres, Elena Ringel, Sebastian Baasch, Julia Kolter, Giulia Cascone, Nikolaos Dokalis, Andreas Vlachos, Zsolt Ruzsics, Philipp Henneke, Marco Prinz, Thomas Blank
Format: Article
Language:English
Published: Nature Portfolio 2023-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-38373-0

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https://doi.org/10.1038/s41467-023-38373-0

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