Neorogioltriol and Related Diterpenes from the Red Alga <i>Laurencia</i> Inhibit Inflammatory Bowel Disease in Mice by Suppressing M1 and Promoting M2-Like Macrophage Responses

Neorogioltriol and Related Diterpenes from the Red Alga <i>Laurencia</i> Inhibit Inflammatory Bowel Disease in Mice by Suppressing M1 and Promoting M2-Like Macrophage Responses

Macrophages are central mediators of inflammation, orchestrating the inflammatory response through the production of cytokines and nitric oxide. Macrophages obtain pro-inflammatory (M1) and anti-inflammatory (M2) phenotypes, which can be modulated by soluble factors, including natural products. Desp...

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Bibliographic Details
Main Authors: Maria G. Daskalaki, Dimitra Vyrla, Maria Harizani, Christina Doxaki, Aristides G. Eliopoulos, Vassilios Roussis, Efstathia Ioannou, Christos Tsatsanis, Sotirios C. Kampranis
Format: Article
Language:English
Published: MDPI AG 2019-02-01
Series:Marine Drugs
Subjects:
<i>Laurencia</i>
halogenated diterpenes
neorogioltriol
cytokine
nitric oxide
TNF-alpha
colitis
Online Access:https://www.mdpi.com/1660-3397/17/2/97

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https://www.mdpi.com/1660-3397/17/2/97

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