An ARHGEF10 deletion is highly associated with a juvenile-onset inherited polyneuropathy in Leonberger and Saint Bernard dogs.

An ARHGEF10 deletion is highly associated with a juvenile-onset inherited polyneuropathy in Leonberger and Saint Bernard dogs.

An inherited polyneuropathy (PN) observed in Leonberger dogs has clinical similarities to a genetically heterogeneous group of peripheral neuropathies termed Charcot-Marie-Tooth (CMT) disease in humans. The Leonberger disorder is a severe, juvenile-onset, chronic, progressive, and mixed PN, characte...

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Bibliographic Details
Main Authors: Kari J Ekenstedt, Doreen Becker, Katie M Minor, G Diane Shelton, Edward E Patterson, Tim Bley, Anna Oevermann, Thomas Bilzer, Tosso Leeb, Cord Drögemüller, James R Mickelson
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-10-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC4183422?pdf=render

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http://europepmc.org/articles/PMC4183422?pdf=render

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