Modelling porcine NAFLD by deletion of leptin and defining the role of AMPK in hepatic fibrosis

Modelling porcine NAFLD by deletion of leptin and defining the role of AMPK in hepatic fibrosis

Abstract Background Non-alcoholic fatty liver disease (NAFLD) is the most prevalent cause of chronic hepatic disease and results in non-alcoholic steatohepatitis (NASH), which progresses to fibrosis and cirrhosis. Although the Leptin deficient rodent models are widely used in study of metabolic synd...

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Bibliographic Details
Main Authors: Tan Tan, Zhiyuan Song, Wenya Li, Runming Wang, Mingli Zhu, Zuoxiang Liang, Yilina Bai, Qi Wang, Hanyu Wu, Xiaoxiang Hu, Yiming Xing
Format: Article
Language:English
Published: BMC 2023-09-01
Series:Cell & Bioscience
Subjects:
Liver fibrosis
LEPTIN
Pig
NAFLD
AMPK pathway
Online Access:https://doi.org/10.1186/s13578-023-01124-1

Internet

https://doi.org/10.1186/s13578-023-01124-1

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