Serological Evidence of Immune Priming by Group A Streptococci in Patients with Acute Rheumatic Fever

Serological Evidence of Immune Priming by Group A Streptococci in Patients with Acute Rheumatic Fever

Acute rheumatic fever (ARF) is an autoimmune response to Group A Streptococcus (GAS) infection. Repeated GAS exposures are proposed to ‘prime’ the immune system for autoimmunity. This notion of immune-priming by multiple GAS infections was first postulated in the 1960s, but direct experimental evide...

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Bibliographic Details
Main Authors: Jeremy M Raynes, Hannah RC Frost, Deborah A Williamson, Paul G Young, Edward N Baker, John D Steemson, Jacelyn M Loh, Thomas Proft, P Rod Dunbar, Polly E Atatoa Carr, Anita Bell, Nicole Jane Moreland
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-07-01
Series:Frontiers in Microbiology
Subjects:
Immunohistochemistry
T-antigen
group A streptococcus
immune priming
acute rheumatic fever
tee-type
Online Access:http://journal.frontiersin.org/Journal/10.3389/fmicb.2016.01119/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fmicb.2016.01119/full

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