Secretory Leucoprotease Inhibitor (SLPI) Promotes Survival during Acute <i>Pseudomonas aeruginosa</i> Infection by Suppression of Inflammation Rather Than Microbial Killing

Secretory Leucoprotease Inhibitor (SLPI) Promotes Survival during Acute <i>Pseudomonas aeruginosa</i> Infection by Suppression of Inflammation Rather Than Microbial Killing

Secretory leucoprotease inhibitor (SLPI) has multifaceted functions, including inhibition of protease activity, antimicrobial functions, and anti-inflammatory properties. In this study, we show that SLPI plays a role in controlling pulmonary <i>Pseudomonas aeruginosa</i> infection. Mice...

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Bibliographic Details
Main Authors: Megan Osbourn, Aoife M. Rodgers, Alice V. Dubois, Donna M. Small, Fiachra Humphries, Nezira Delagic, Paul N. Moynagh, Sinéad Weldon, Clifford C. Taggart, Rebecca J. Ingram
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Biomolecules
Subjects:
secretory leucoprotease inhibitor
SLPI
inflammation
infection
Pseudomonas
Online Access:https://www.mdpi.com/2218-273X/12/12/1728

Internet

https://www.mdpi.com/2218-273X/12/12/1728

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