The Designed Pore-Forming Antimicrobial Peptide C14R Combines Excellent Activity against the Major Opportunistic Human Pathogen <i>Pseudomonas aeruginosa</i> with Low Cytotoxicity

The Designed Pore-Forming Antimicrobial Peptide C14R Combines Excellent Activity against the Major Opportunistic Human Pathogen <i>Pseudomonas aeruginosa</i> with Low Cytotoxicity

The diminishing portfolio of mankind’s available antibiotics urges science to develop novel potent drugs. Here, we present a peptide fitting the typical blueprint of amphipathic and membrane-active antimicrobial peptides, denominated C14R. This 2 kDa peptide consists of 16 amino acid residues, with...

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Bibliographic Details
Main Authors: Vanessa Mildenberger, Daniel Alpízar-Pedraza, Ernesto M. Martell-Huguet, Markus Krämer, Grigory Bolotnikov, Anselmo J. Otero-Gonzalez, Tanja Weil, Armando Rodriguez-Alfonso, Nico Preising, Ludger Ständker, Verena Vogel, Barbara Spellerberg, Ann-Kathrin Kissmann, Frank Rosenau
Format: Article
Language:English
Published: MDPI AG 2024-01-01
Series:Pharmaceuticals
Subjects:
antimicrobial peptides
clinical isolates
pore-formation
<i>Pseudomonas aeruginosa</i>
Online Access:https://www.mdpi.com/1424-8247/17/1/83

Internet

https://www.mdpi.com/1424-8247/17/1/83

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