Anti-tumoral effect of the mitochondrial target domain of Noxa delivered by an engineered Salmonella typhimurium.

Bacterial cancer therapy relies on the fact that several bacterial species are capable of targeting tumor tissue and that bacteria can be genetically engineered to selectively deliver therapeutic proteins of interest to the targeted tumors. However, the challenge of bacterial cancer therapy is the r...

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Main Authors: Jae-Ho Jeong, Kwangsoo Kim, Daejin Lim, Kwangjoon Jeong, Yeongjin Hong, Vu H Nguyen, Tae-Hyoung Kim, Sangryeol Ryu, Jeong-A Lim, Jae Il Kim, Geun-Joong Kim, Sun Chang Kim, Jung-Joon Min, Hyon E Choy
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3885380?pdf=render