BM-MSCs display altered gene expression profiles in B-cell acute lymphoblastic leukemia niches and exert pro-proliferative effects via overexpression of IFI6

BM-MSCs display altered gene expression profiles in B-cell acute lymphoblastic leukemia niches and exert pro-proliferative effects via overexpression of IFI6

Abstract Background The tumor microenvironment (TME) is a supportive environment responsible for promoting the growth and proliferation of tumor cells. Current studies have revealed that the bone marrow mesenchymal stem cells (BM-MSCs), a type of crucial stromal cells in the TME, can promote the mal...

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Bibliographic Details
Main Authors: Chengyun Pan, Tianzhen Hu, Ping Liu, Dan Ma, Shuyun Cao, Qin Shang, Luxin Zhang, Qingzhen Chen, Qin Fang, Jishi Wang
Format: Article
Language:English
Published: BMC 2023-09-01
Series:Journal of Translational Medicine
Subjects:
B-cell acute lymphoblastic leukemia
Tumor microenvironment
Mesenchymal stem cells
Interferon alpha-inducible protein 6
Proliferation
Online Access:https://doi.org/10.1186/s12967-023-04464-1

Internet

https://doi.org/10.1186/s12967-023-04464-1

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