Investigating cell-specific effects of FMRP deficiency on spiny projection neurons in a mouse model of Fragile X syndrome

Investigating cell-specific effects of FMRP deficiency on spiny projection neurons in a mouse model of Fragile X syndrome

IntroductionFragile X syndrome (FXS), resulting from a mutation in the Fmr1 gene, is the most common monogenic cause of autism and inherited intellectual disability. Fmr1 encodes the Fragile X Messenger Ribonucleoprotein (FMRP), and its absence leads to cognitive, emotional, and social deficits comp...

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Bibliographic Details
Main Authors: Gabriele Giua, Olivier Lassalle, Leila Makrini-Maleville, Emmanuel Valjent, Pascale Chavis, Olivier J. J. Manzoni
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Fragile X
accumbens
D1R
D2R
spiny projection neurons
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2023.1146647/full

Internet

https://www.frontiersin.org/articles/10.3389/fncel.2023.1146647/full

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