Biomimetic nanoparticles to enhance the reverse cholesterol transport for selectively inhibiting development into foam cell in atherosclerosis

Biomimetic nanoparticles to enhance the reverse cholesterol transport for selectively inhibiting development into foam cell in atherosclerosis

Abstract A disorder of cholesterol homeostasis is one of the main initiating factors in the progression of atherosclerosis (AS). Metabolism and removal of excess cholesterol facilitates the prevention of foam cell formation. However, the failure of treatment with drugs (e.g. methotrexate, MTX) to ef...

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Bibliographic Details
Main Authors: Li Zhu, Hongjiao Li, Jiyu Li, Yuan Zhong, Shuai Wu, Meng Yan, Sheng Ni, Kun Zhang, Guixue Wang, Kai Qu, Deqin Yang, Xian Qin, Wei Wu
Format: Article
Language:English
Published: BMC 2023-08-01
Series:Journal of Nanobiotechnology
Subjects:
Biomimetic nanoparticles
Atherosclerosis
Macrophage membrane
Methotrexate
Cholesterol efflux
Target delivery
Online Access:https://doi.org/10.1186/s12951-023-02040-9

Internet

https://doi.org/10.1186/s12951-023-02040-9

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