Synthesis of 1,5-Substituted Pyrrolidin-2-ones from Donor–Acceptor Cyclopropanes and Anilines/Benzylamines

Synthesis of 1,5-Substituted Pyrrolidin-2-ones from Donor–Acceptor Cyclopropanes and Anilines/Benzylamines

We developed a straightforward synthetic route to pharmacologically important 1,5-substituted pyrrolidin-2-ones from donor–acceptor cyclopropanes bearing an ester group as one of the acceptor substituents. This method includes a Lewis acid-catalyzed opening of the donor–acceptor cyclopropane with pr...

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Bibliographic Details
Main Authors: Maksim A. Boichenko, Andrey Yu. Plodukhin, Vitaly V. Shorokhov, Danyla S. Lebedev, Anastasya V. Filippova, Sergey S. Zhokhov, Elena A. Tarasenko, Victor B. Rybakov, Igor V. Trushkov, Olga A. Ivanova
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Molecules
Subjects:
donor–acceptor cyclopropanes
primary amines
pyrrolidin-2-ones
benz[<i>g</i>]indolizidines
Online Access:https://www.mdpi.com/1420-3049/27/23/8468

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https://www.mdpi.com/1420-3049/27/23/8468

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