TLR4/Inflammasomes Cross-Talk and Pyroptosis Contribute to N-Acetyl Cysteine and Chlorogenic Acid Protection against Cisplatin-Induced Nephrotoxicity

TLR4/Inflammasomes Cross-Talk and Pyroptosis Contribute to N-Acetyl Cysteine and Chlorogenic Acid Protection against Cisplatin-Induced Nephrotoxicity

Background: Cisplatin (Cp) is an antineoplastic agent with a dose-limiting nephrotoxicity. Cp-induced nephrotoxicity is characterized by the interplay of oxidative stress, inflammation, and apoptosis. Toll-4 receptors (TLR4) and NLPR3 inflammasome are pattern-recognition receptors responsible for ac...

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Bibliographic Details
Main Authors: Amira M. Badr, Layla A. Al-Kharashi, Hala Attia, Samiyah Alshehri, Hanaa N. Alajami, Rehab A. Ali, Yasmen F. Mahran
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Pharmaceuticals
Subjects:
cisplatin
nephrotoxicity
TLR4
inflammasomes
NLPR3
N-acetylcysteine
Online Access:https://www.mdpi.com/1424-8247/16/3/337

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https://www.mdpi.com/1424-8247/16/3/337

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