Pathological characteristics of axons and alterations of proteomic and lipidomic profiles in midbrain dopaminergic neurodegeneration induced by WDR45-deficiency

Pathological characteristics of axons and alterations of proteomic and lipidomic profiles in midbrain dopaminergic neurodegeneration induced by WDR45-deficiency

Abstract Background Although WD repeat domain 45 (WDR45) mutations have been linked to $$\upbeta$$ β -propeller protein-associated neurodegeneration (BPAN), the precise molecular and cellular mechanisms behind this disease remain elusive. This study aims to shed light on the impacts of WDR45-deficie...

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Bibliographic Details
Main Authors: Panpan Wang, Yaping Shao, Murad Al-Nusaif, Jun Zhang, Huijia Yang, Yuting Yang, Kunhyok Kim, Song Li, Cong Liu, Huaibin Cai, Weidong Le
Format: Article
Language:English
Published: BMC 2024-08-01
Series:Molecular Neurodegeneration
Subjects:
WDR45
Axonal degeneration
Autophagy
Tubular ER
Phospholipid metabolism
Lpcat1
Online Access:https://doi.org/10.1186/s13024-024-00746-4

Internet

https://doi.org/10.1186/s13024-024-00746-4

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