Mechanisms and efficacy of metformin-mediated suppression of established experimental abdominal aortic aneurysms

Mechanisms and efficacy of metformin-mediated suppression of established experimental abdominal aortic aneurysms

Objective: Metformin treatment attenuates experimental abdominal aortic aneurysm (AAA) formation, as well as reduces clinical AAA diameter enlargement in patients with diabetes. The mechanisms of metformin-mediated aneurysm suppression, and its efficacy in suppressing established experimental aneury...

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Bibliographic Details
Main Authors: Baohui Xu, MD, PhD, Gang Li, MD, PhD, Yankui Li, MD, PhD, Hongping Deng, MD, PhD, Anna Cabot, BS, Jia Guo, MD, PhD, Makoto Samura, MD, PhD, Xiaoya Zheng, MD, PhD, Tiffany Chen, BS, Sihai Zhao, MD, PhD, Naoki Fujimura, MD, PhD, Ronald L. Dalman, MD
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:JVS - Vascular Science
Subjects:
Abdominal aortic aneurysm
5′ AMP-activated protein kinase
Cytokine
Inflammatory monocytes
Metformin
Online Access:http://www.sciencedirect.com/science/article/pii/S2666350323000068

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http://www.sciencedirect.com/science/article/pii/S2666350323000068

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