N-Methyl-D-aspartate (NMDA) and cannabinoid CB2 receptors form functional complexes in cells of the central nervous system: insights into the therapeutic potential of neuronal and microglial NMDA receptors

N-Methyl-D-aspartate (NMDA) and cannabinoid CB2 receptors form functional complexes in cells of the central nervous system: insights into the therapeutic potential of neuronal and microglial NMDA receptors

Abstract Background The cannabinoid CB2 receptor (CB2R), which is a target to afford neuroprotection, and N-methyl-D-aspartate (NMDA) ionotropic glutamate receptors, which are key in mediating excitatory neurotransmission, are expressed in both neurons and glia. As NMDA receptors are the target of c...

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Bibliographic Details
Main Authors: Rafael Rivas-Santisteban, Alejandro Lillo, Jaume Lillo, Joan-Biel Rebassa, Joan S. Contestí, Carlos A. Saura, Rafael Franco, Gemma Navarro
Format: Article
Language:English
Published: BMC 2021-11-01
Series:Alzheimer’s Research & Therapy
Subjects:
Alzheimer’s disease
Neuroprotection
G-protein-coupled receptors
Excitotoxicity
Online Access:https://doi.org/10.1186/s13195-021-00920-6

Internet

https://doi.org/10.1186/s13195-021-00920-6

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