Immunodeficiency and autoimmunity: companions not opposites
Autoimmunity has long been regarded as the polar opposite of immunodeficiency, but clinical and experimental evidence refute this notion. Indeed, numerous inborn or acquired immunodeficiency syndromes are characterized by the development of autoimmune complications in the setting of deficient immune...
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| Format: | Article |
| Language: | English |
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American Society for Clinical Investigation
2022-08-01
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| Series: | The Journal of Clinical Investigation |
| Online Access: | https://doi.org/10.1172/JCI162170 |
| _version_ | 1797634553482838016 |
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| author | David A. Fox |
| author_facet | David A. Fox |
| author_sort | David A. Fox |
| collection | DOAJ |
| description | Autoimmunity has long been regarded as the polar opposite of immunodeficiency, but clinical and experimental evidence refute this notion. Indeed, numerous inborn or acquired immunodeficiency syndromes are characterized by the development of autoimmune complications in the setting of deficient immune defenses against microbial pathogens. Appreciation that much of the daily business of a healthy immune system is the avoidance of potentially harmful responses to innocuous environmental antigens or components of the host organism helps provide a context for these observations. In this issue of the JCI, Abt and colleagues report on purine nucleoside phosphorylase (PNP) deficiency, exploring the basis for the autoimmune complications that develop in this particular form of T cell immune deficiency and assigning a key role for overactivation of TLR7. |
| first_indexed | 2024-03-11T12:09:22Z |
| format | Article |
| id | doaj.art-0255ea57390542219094ae682488b34a |
| institution | Directory Open Access Journal |
| issn | 1558-8238 |
| language | English |
| last_indexed | 2024-03-11T12:09:22Z |
| publishDate | 2022-08-01 |
| publisher | American Society for Clinical Investigation |
| record_format | Article |
| series | The Journal of Clinical Investigation |
| spelling | doaj.art-0255ea57390542219094ae682488b34a2023-11-07T16:19:14ZengAmerican Society for Clinical InvestigationThe Journal of Clinical Investigation1558-82382022-08-0113216Immunodeficiency and autoimmunity: companions not oppositesDavid A. FoxAutoimmunity has long been regarded as the polar opposite of immunodeficiency, but clinical and experimental evidence refute this notion. Indeed, numerous inborn or acquired immunodeficiency syndromes are characterized by the development of autoimmune complications in the setting of deficient immune defenses against microbial pathogens. Appreciation that much of the daily business of a healthy immune system is the avoidance of potentially harmful responses to innocuous environmental antigens or components of the host organism helps provide a context for these observations. In this issue of the JCI, Abt and colleagues report on purine nucleoside phosphorylase (PNP) deficiency, exploring the basis for the autoimmune complications that develop in this particular form of T cell immune deficiency and assigning a key role for overactivation of TLR7.https://doi.org/10.1172/JCI162170 |
| spellingShingle | David A. Fox Immunodeficiency and autoimmunity: companions not opposites The Journal of Clinical Investigation |
| title | Immunodeficiency and autoimmunity: companions not opposites |
| title_full | Immunodeficiency and autoimmunity: companions not opposites |
| title_fullStr | Immunodeficiency and autoimmunity: companions not opposites |
| title_full_unstemmed | Immunodeficiency and autoimmunity: companions not opposites |
| title_short | Immunodeficiency and autoimmunity: companions not opposites |
| title_sort | immunodeficiency and autoimmunity companions not opposites |
| url | https://doi.org/10.1172/JCI162170 |
| work_keys_str_mv | AT davidafox immunodeficiencyandautoimmunitycompanionsnotopposites |