Fc–Fc interactions and immune inhibitory effects of IgG4: implications for anti-PD-1 immunotherapies

Fc–Fc interactions and immune inhibitory effects of IgG4: implications for anti-PD-1 immunotherapies

Background The majority of anti-programmed cell-death 1 (PD-1) monoclonal antibodies (mAbs) use S228P mutation IgG4 as the structural basis to avoid the activation of immune cells or complement. However, little attention has been paid to the Fc–Fc interactions between IgG4 and other IgG Fc fragments...

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Bibliographic Details
Main Authors: Hui Wang, Yu Xia, Meng Su, Baiyong Li, Xingxing Chen, Weifeng Zhang, Xueling Chen, Jirui Li, Xiaomiao Yan, Han Zha, Xiaonan Ma, Chanyuan Zhao, Liangli Hong, Penghao Li, Yanyu Ling, Wenhui Zhao, Tianjing Zheng, Jiang Gu
Format: Article
Language:English
Published: BMJ Publishing Group 2024-06-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/12/6/e009034.full

Internet

https://jitc.bmj.com/content/12/6/e009034.full

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