Mitochondria are secreted in extracellular vesicles when lysosomal function is impaired

Mitochondria are secreted in extracellular vesicles when lysosomal function is impaired

Abstract Mitochondrial quality control is critical for cardiac homeostasis as these organelles are responsible for generating most of the energy needed to sustain contraction. Dysfunctional mitochondria are normally degraded via intracellular degradation pathways that converge on the lysosome. Here,...

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Bibliographic Details
Main Authors: Wenjing Liang, Shakti Sagar, Rishith Ravindran, Rita H. Najor, Justin M. Quiles, Liguo Chi, Rachel Y. Diao, Benjamin P. Woodall, Leonardo J. Leon, Erika Zumaya, Jason Duran, David M. Cauvi, Antonio De Maio, Eric D. Adler, Åsa B. Gustafsson
Format: Article
Language:English
Published: Nature Portfolio 2023-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-40680-5

Internet

https://doi.org/10.1038/s41467-023-40680-5

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