The BMP Receptor 2 in Pulmonary Arterial Hypertension: When and Where the Animal Model Matches the Patient

The BMP Receptor 2 in Pulmonary Arterial Hypertension: When and Where the Animal Model Matches the Patient

<b>Background:</b> Mutations in bone morphogenetic protein receptor type II (BMPR2) are leading to the development of hereditary pulmonary arterial hypertension (PAH). In non-hereditary forms of PAH, perturbations in the transforming growth factor-β (TGF-β)/BMP-axis are believed to cause...

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Bibliographic Details
Main Authors: Chris Happé, Kondababu Kurakula, Xiao-Qing Sun, Denielli da Silva Goncalves Bos, Nina Rol, Christophe Guignabert, Ly Tu, Ingrid Schalij, Karien C. Wiesmeijer, Olga Tura-Ceide, Anton Vonk Noordegraaf, Frances S. de Man, Harm Jan Bogaard, Marie-José Goumans
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:Cells
Subjects:
pulmonary arterial hypertension
BMPR2
BMP and TGF-β signaling
animal models of pulmonary hypertension
Online Access:https://www.mdpi.com/2073-4409/9/6/1422

Internet

https://www.mdpi.com/2073-4409/9/6/1422

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