Multi-Functionalized Heteroduplex Antisense Oligonucleotides for Targeted Intracellular Delivery and Gene Silencing in HeLa Cells

Multi-Functionalized Heteroduplex Antisense Oligonucleotides for Targeted Intracellular Delivery and Gene Silencing in HeLa Cells

Oligonucleotide therapeutics, antisense oligonucleotides (ASOs) and short interfering RNA (siRNA) are short synthetic nucleic acid molecules with a promising potential to treat a wide range of diseases. Despite considerable progress in the field, the development of safe and effective delivery system...

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Bibliographic Details
Main Authors: Mauro Sousa de Almeida, Barbara Rothen-Rutishauser, Michael Mayer, Maria Taskova
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Biomedicines
Subjects:
oligonucleotide therapeutics
delivery
modified oligonucleotides
multi-functionalization
gene knockdown
Online Access:https://www.mdpi.com/2227-9059/10/9/2096

Internet

https://www.mdpi.com/2227-9059/10/9/2096

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