Unveiling behavioral and molecular neuroadaptations related to the antidepressant action of cannabidiol in the unpredictable chronic mild stress model

Unveiling behavioral and molecular neuroadaptations related to the antidepressant action of cannabidiol in the unpredictable chronic mild stress model

Introduction: This study aims to further characterize cannabidiol’s pharmacological and molecular profile as an antidepressant.Methods: Effects of cannabidiol (CBD), alone or combined with sertraline (STR), were evaluated in male CD1 mice (n = 48) exposed to an unpredictable chronic mild stress (UCM...

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Bibliographic Details
Main Authors: María Salud García-Gutiérrez, Daniela Navarro, Amaya Austrich-Olivares, Jorge Manzanares
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-04-01
Series:Frontiers in Pharmacology
Subjects:
cannabidiol
unpredictable chronic mild stress model
sertraline
neuroplasticity
mice
antidepressant properties
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1171646/full

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https://www.frontiersin.org/articles/10.3389/fphar.2023.1171646/full

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