Early brain loss in circuits affected by Alzheimer’s disease is predicted by fornix microstructure but may be independent of gray matter

Early brain loss in circuits affected by Alzheimer’s disease is predicted by fornix microstructure but may be independent of gray matter

In a cohort of community-recruited elderly subjects with normal cognition at initial evaluation, we found that baseline fornix white matter microstructure was significantly correlated with early volumetric longitudinal tissue change across a region of interest (called fSROI), which overlaps circuits...

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Bibliographic Details
Main Authors: Evan eFletcher, Owen eCarmichael, Ofer ePasternak, Klaus H Maier-Hein, Charles eDeCarli
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-05-01
Series:Frontiers in Aging Neuroscience
Subjects:
Default Mode Network
fornix diffusivity
longitudinal brain change
limbic circuit
normal cognition
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnagi.2014.00106/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnagi.2014.00106/full

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