HuD Regulates Coding and Noncoding RNA to Induce APP→Aβ Processing

HuD Regulates Coding and Noncoding RNA to Induce APP→Aβ Processing

The primarily neuronal RNA-binding protein HuD is implicated in learning and memory. Here, we report the identification of several HuD target transcripts linked to Alzheimer’s disease (AD) pathogenesis. HuD interacted with the 3′ UTRs of APP mRNA (encoding amyloid precursor protein) and BACE1 mRNA (...

Full description

Bibliographic Details
Main Authors: Min-Ju Kang, Kotb Abdelmohsen, Emmette R. Hutchison, Sarah J. Mitchell, Ioannis Grammatikakis, Rong Guo, Ji Heon Noh, Jennifer L. Martindale, Xiaoling Yang, Eun Kyung Lee, Mohammad A. Faghihi, Claes Wahlestedt, Juan C. Troncoso, Olga Pletnikova, Nora Perrone-Bizzozero, Susan M. Resnick, Rafael de Cabo, Mark P. Mattson, Myriam Gorospe
Format: Article
Language:English
Published: Elsevier 2014-06-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124714003520

Internet

http://www.sciencedirect.com/science/article/pii/S2211124714003520

Similar Items