Melatonin Attenuates Dasatinib-Aggravated Hypoxic Pulmonary Hypertension via Inhibiting Pulmonary Vascular Remodeling

Melatonin Attenuates Dasatinib-Aggravated Hypoxic Pulmonary Hypertension via Inhibiting Pulmonary Vascular Remodeling

Dasatinib treatment is approved as first-line therapy for chronic myeloid leukemia. However, pulmonary hypertension (PH) is a highly morbid and often fatal side-effect of dasatinib, characterized by progressive pulmonary vascular remodeling. Melatonin exerts strong antioxidant capacity against the p...

Deskribapen osoa

Xehetasun bibliografikoak
Egile Nagusiak: Rui Wang, Jinjin Pan, Jinzhen Han, Miaomiao Gong, Liang Liu, Yunlong Zhang, Ying Liu, Dingyou Wang, Qing Tang, Na Wu, Lin Wang, Jinsong Yan, Hua Li, Yuhui Yuan
Formatua: Artikulua
Hizkuntza:English
Argitaratua: Frontiers Media S.A. 2022-03-01
Saila:Frontiers in Cardiovascular Medicine
Gaiak:
melatonin
dasatinib
pulmonary hypertension
vascular remodeling
hypoxia
oxidative stress
Sarrera elektronikoa:https://www.frontiersin.org/articles/10.3389/fcvm.2022.790921/full

Internet

https://www.frontiersin.org/articles/10.3389/fcvm.2022.790921/full

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