In Cellulo Evaluation of the Therapeutic Potential of NHC Platinum Compounds in Metastatic Cutaneous Melanoma

In Cellulo Evaluation of the Therapeutic Potential of NHC Platinum Compounds in Metastatic Cutaneous Melanoma

We describe here the evaluation of the cytotoxic efficacy of two platinum (II) complexes bearing an N-heterocyclic carbene (NHC) ligand, a pyridine ligand and bromide or iodide ligands on a panel of human metastatic cutaneous melanoma cell lines representing different genetic subsets including BRAF-...

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Bibliographic Details
Main Authors: Elsa Charignon, Mathilde Bouché, Caroline Clave-Darcissac, Georges Dahm, Gabriel Ichim, Anthony Clotagatide, Hichem C. Mertani, Philippe Telouk, Julie Caramel, Jean-Jacques Diaz, Stéphane Bellemin-Laponnaz, Philippe Bouvet, Claire Billotey
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:International Journal of Molecular Sciences
Subjects:
platinum N-heterocyclic carbene complexes
metastatic cutaneous melanoma
chemotherapy
BRAF inhibitor resistance
apoptosis
chemoresistance
Online Access:https://www.mdpi.com/1422-0067/21/21/7826

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https://www.mdpi.com/1422-0067/21/21/7826

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