Secukinumab and Black Garlic Downregulate OPG/RANK/RANKL Axis and Devitalize Myocardial Interstitial Fibrosis Induced by Sunitinib in Experimental Rats

Sunitinib has been associated with several cardiotoxic effects such as cardiac fibrosis. The present study was designed to explore the role of interleukin (IL)-17 in sunitinib-induced myocardial fibrosis (MF) in rats and whether its neutralization and/or administration of black garlic (BG), a form o...

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Bibliographic Details
Main Authors: Hoda E. Mohamad, Mervat E. Asker, Mohamed A. Shaheen, Nourhan M. Baraka, Omer I. Fantoukh, Abdulaziz Alqahtani, Alaa E. Salama, Yasmin K. Mahmoud
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Life
Subjects:
Online Access:https://www.mdpi.com/2075-1729/13/2/308