Synergetic delivery of artesunate and isosorbide 5-mononitrate with reduction-sensitive polymer nanoparticles for ovarian cancer chemotherapy

Synergetic delivery of artesunate and isosorbide 5-mononitrate with reduction-sensitive polymer nanoparticles for ovarian cancer chemotherapy

Abstract Ovarian cancer is a highly fatal gynecologic malignancy worldwide. Chemotherapy remains the primary modality both for primary and maintenance treatments of ovarian cancer. However, the progress in developing chemotherapeutic agents for ovarian cancer has been slow in the past 20 years. Thus...

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Bibliographic Details
Main Authors: Guang Li, Mingjian Ling, Kunyi Yu, Wei Yang, Qiwen Liu, Lijuan He, Xuzi Cai, Min Zhong, Ziyi Mai, Rui Sun, Yuanling Xiao, Zhiqiang Yu, Xuefeng Wang
Format: Article
Language:English
Published: BMC 2022-11-01
Series:Journal of Nanobiotechnology
Subjects:
Artesunate
Isosorbide 5-mononitrate
DNA damage
Mitochondrial damage
Cell cycle arrest
Ovarian cancer
Online Access:https://doi.org/10.1186/s12951-022-01676-3

Internet

https://doi.org/10.1186/s12951-022-01676-3

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