Binding asymmetry and conformational studies of the AtGSDA dimer

Binding asymmetry and conformational studies of the AtGSDA dimer

Guanosine deaminase (GSDA) is an important deaminase that converts guanosine to xanthosine, a key intermediate in nitrogen recycling in plants. We previously solved complex structures of Arabidopsis thaliana GSDA bound by various ligands and examined its catalytic mechanism. Here, we report cocrysta...

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Bibliographic Details
Main Authors: Qian Jia, Hui Zeng, Mingwei Li, Jing Tang, Nan Xiao, Shangfang Gao, Huanxi Li, Jinbing Zhang, Zhiyong Zhang, Wei Xie
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:Computational and Structural Biotechnology Journal
Subjects:
Binding asymmetry
Guanosine deaminase
Molecular dynamics simulation
Purine metabolism
Unequal conformation
Online Access:http://www.sciencedirect.com/science/article/pii/S2001037023004208

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http://www.sciencedirect.com/science/article/pii/S2001037023004208

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