The alpha-synuclein oligomers activate nuclear factor of activated T-cell (NFAT) modulating synaptic homeostasis and apoptosis

The alpha-synuclein oligomers activate nuclear factor of activated T-cell (NFAT) modulating synaptic homeostasis and apoptosis

Abstract Background Soluble oligomeric forms of alpha-synuclein (aSyn-O) are believed to be one of the main toxic species in Parkinson’s disease (PD) leading to degeneration. aSyn-O can induce Ca2+ influx, over activating downstream pathways leading to PD phenotype. Calcineurin (CN), a phosphatase r...

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Bibliographic Details
Main Authors: Ricardo Sant’Anna, Bruno K. Robbs, Júlia Araújo de Freitas, Patrícia Pires dos Santos, Annekatrin König, Tiago Fleming Outeiro, Debora Foguel
Format: Article
Language:English
Published: BMC 2023-08-01
Series:Molecular Medicine
Subjects:
Alpha-synuclein
Synucleinopathies
Parkinson’s disease
NFAT
Synapsin 1
Synapses
Online Access:https://doi.org/10.1186/s10020-023-00704-8

Internet

https://doi.org/10.1186/s10020-023-00704-8

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