Sensitivity of MRI tumor biomarkers to VEGFR inhibitor therapy in an orthotopic mouse glioma model.

Sensitivity of MRI tumor biomarkers to VEGFR inhibitor therapy in an orthotopic mouse glioma model.

MRI biomarkers of tumor edema, vascular permeability, blood volume, and average vessel caliber are increasingly being employed to assess the efficacy of tumor therapies. However, the dependence of these biomarkers on a number of physiological factors can compromise their sensitivity and complicate t...

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Bibliographic Details
Main Authors: Christian T Farrar, Walid S Kamoun, Carsten D Ley, Young R Kim, Ciprian Catana, Seon J Kwon, Bruce R Rosen, Rakesh K Jain, A Gregory Sorensen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-03-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3048404?pdf=render

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http://europepmc.org/articles/PMC3048404?pdf=render

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