Retinoic Acid Receptors Control Spermatogonia Cell-Fate and Induce Expression of the SALL4A Transcription Factor.

Retinoic Acid Receptors Control Spermatogonia Cell-Fate and Induce Expression of the SALL4A Transcription Factor.

All-trans retinoic acid (ATRA) is instrumental to male germ cell differentiation, but its mechanism of action remains elusive. To address this question, we have analyzed the phenotypes of mice lacking, in spermatogonia, all rexinoid receptors (RXRA, RXRB and RXRG) or all ATRA receptors (RARA, RARB a...

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Bibliographic Details
Main Authors: Aurore Gely-Pernot, Mathilde Raverdeau, Marius Teletin, Nadège Vernet, Betty Féret, Muriel Klopfenstein, Christine Dennefeld, Irwin Davidson, Gérard Benoit, Manuel Mark, Norbert B Ghyselinck
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-10-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC4591280?pdf=render

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http://europepmc.org/articles/PMC4591280?pdf=render

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