ELK4 Promotes Colorectal Cancer Progression by Activating the Neoangiogenic Factor LRG1 in a Noncanonical SP1/3‐Dependent Manner

ELK4 Promotes Colorectal Cancer Progression by Activating the Neoangiogenic Factor LRG1 in a Noncanonical SP1/3‐Dependent Manner

Abstract Although the MAPK/MEK/ERK pathway is prevalently activated in colorectal cancer (CRC), MEK/ERK inhibitors show limited efficiency in clinic. As a downstream target of MAPK, ELK4 is thought to work primarily by forming a complex with SRF. Whether ELK4 can serve as a potential therapeutic tar...

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Bibliographic Details
Main Authors: Zhehui Zhu, Yuegui Guo, Yun Liu, Rui Ding, Zhenyu Huang, Wei Yu, Long Cui, Peng Du, Ajay Goel, Chen‐Ying Liu
Format: Article
Language:English
Published: Wiley 2023-11-01
Series:Advanced Science
Subjects:
colorectal cancer
ELK4
LRG1
SP1
SP3
Online Access:https://doi.org/10.1002/advs.202303378

Internet

https://doi.org/10.1002/advs.202303378

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