CRISPRi-Guided Metabolic Flux Engineering for Enhanced Protopanaxadiol Production in <i>Saccharomyces cerevisiae</i>

CRISPRi-Guided Metabolic Flux Engineering for Enhanced Protopanaxadiol Production in <i>Saccharomyces cerevisiae</i>

Protopanaxadiol (PPD), an aglycon found in several dammarene-type ginsenosides, has high potency as a pharmaceutical. Nevertheless, application of these ginsenosides has been limited because of the high production cost due to the rare content of PPD in <i>Panax ginseng</i> and a long cul...

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Bibliographic Details
Main Authors: Soo-Hwan Lim, Jong-In Baek, Byeong-Min Jeon, Jung-Woo Seo, Min-Sung Kim, Ji-Young Byun, Soo-Hoon Park, Su-Jin Kim, Ju-Young Lee, Jun-Hyoung Lee, Sun-Chang Kim
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:International Journal of Molecular Sciences
Subjects:
CRISPR interference
lanosterol
protopanaxadiol
triterpenes
metabolic engineering
ginsenosides
Online Access:https://www.mdpi.com/1422-0067/22/21/11836

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https://www.mdpi.com/1422-0067/22/21/11836

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