Conformational alteration in glycan induces phospholipase Cβ1 activation and angiogenesis

Conformational alteration in glycan induces phospholipase Cβ1 activation and angiogenesis

Abstract Background In endothelial cells, phospholipase C (PLC) β1-activated Ca2+ is a crucial second messenger for the signaling pathways governing angiogenesis. PLCβ1 is inactivated by complexing with an intracellular protein called translin-associated factor X (TRAX). This study demonstrates spec...

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Bibliographic Details
Main Authors: Sheng-Hung Wang, Jing-Yan Cheng, Hsiu-Hui Tsai, Tzu-Chi Lo, Jung-Tung Hung, Chun-Cheng Lin, Chien-Wei Lee, Yi-Hsuan Ho, Huan-Hsien Kuo, Alice L. Yu, John Yu
Format: Article
Language:English
Published: BMC 2022-12-01
Series:Journal of Biomedical Science
Subjects:
Globo H ceramide
TRAX
Phospholipase Cβ1
Angiogenesis
Glycosphingolipids
Extracellular vesicles
Online Access:https://doi.org/10.1186/s12929-022-00889-w

Internet

https://doi.org/10.1186/s12929-022-00889-w

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