Integrated Isogenic Human Induced Pluripotent Stem Cell–Based Liver and Heart Microphysiological Systems Predict Unsafe Drug–Drug Interaction

Integrated Isogenic Human Induced Pluripotent Stem Cell–Based Liver and Heart Microphysiological Systems Predict Unsafe Drug–Drug Interaction

Three-dimensional (3D) microphysiological systems (MPSs) mimicking human organ function in vitro are an emerging alternative to conventional monolayer cell culture and animal models for drug development. Human induced pluripotent stem cells (hiPSCs) have the potential to capture the diversity of hum...

Full description

Bibliographic Details
Main Authors: Felipe T. Lee-Montiel, Alexander Laemmle, Verena Charwat, Laure Dumont, Caleb S. Lee, Nathaniel Huebsch, Hideaki Okochi, Matthew J. Hancock, Brian Siemons, Steven C. Boggess, Ishan Goswami, Evan W. Miller, Holger Willenbring, Kevin E. Healy
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Pharmacology
Subjects:
drug–drug interaction
microphysiological systems
liver and heart integration
ketoconazole
cisapride
hiPSC-derived cells
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.667010/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.667010/full

Similar Items