Rapid and specific chromatography method on monolithic RP-column for determination of high-dose methotrexate pharmacokinetics in sera of cancer patients admitted to Shiraz Amir Hospital
Introduction: methotrexate (MTX) is a routinely used antifolate for the treatment of solid tumors and hematologic malignancies. However, high-dose MTX can lead to severe side effects and the patients are required to receive leucovorin rescue. Hence, we aimed to develop a fast and specific HPLC metho...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Shiraz University of Medical Sciences
2020-09-01
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| Series: | Trends in Pharmaceutical Sciences |
| Subjects: | |
| Online Access: | https://tips.sums.ac.ir/article_46873_d62d52843fe6f98f875be36b384b28d8.pdf |