Extracellular vesicles from subjects with COPD modulate cancer initiating cells phenotype through HIF-1α shuttling

Extracellular vesicles from subjects with COPD modulate cancer initiating cells phenotype through HIF-1α shuttling

Abstract Chronic obstructive pulmonary disease (COPD) is a risk factor for lung cancer development. COPD induces activation of hypoxia-induced signaling, causing remodeling of surrounding microenvironmental cells also modulating the release and cargo of their extracellular vesicles (EVs). We aimed t...

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Bibliographic Details
Main Authors: Ilaria Petraroia, Patrizia Ghidotti, Giulia Bertolini, Francesca Pontis, Luca Roz, Melissa Balsamo, Paola Suatoni, Ugo Pastorino, Anna Maria Ferretti, Gabriella Sozzi, Orazio Fortunato
Format: Article
Language:English
Published: Nature Publishing Group 2023-10-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-023-06212-1

Internet

https://doi.org/10.1038/s41419-023-06212-1

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